Chlorpropamide-induced pure white cell aplasia
نویسندگان
چکیده
منابع مشابه
Chlorpropamide - Induced Pure White Cell
We investigated the mechanism for isolated agranulocytosis and marrow pure white cell aplasia in an elderly man receiving 0.5 to 1 .0 g per day of chlorpropamide (Chl) without other toxic drug exposure or overt systemic illness. Patient marrow revealed an absence of recognizable granulocytic precursors; megakaryocytes and erythroid precursors were normal. The WBC count was 1800/ mm3 on admissio...
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Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with no...
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Long-term administration of azathioprine is widely used to prevent rejection in organ transplantation and in the treatment of autoimmune diseases. Bone marrow toxicity is a well-known side-effect of azathioprine. Macrocytosis, with or without megaloblastic erythropoiesis in the bone marrow, and (mild) leukopenia are frequently seen [1-4]. Less common effects are anaemia, thrombocytopenia and pa...
متن کاملDiphenylhydantoin-induced pure red cell aplasia.
Pure red cell aplasia is an uncommon complication of diphenylhydantoin therapy. It has not been reported in Indian literature. Awareness of the entity helps in establishing the cause of anaemia in these patients and alerts the physicians to the need of comprehensive haematological monitoring in these patients. A case of 58-year-old male who developed pure red cell aplasia following three months...
متن کاملDiphenyihydantoin - Induced Pure Red Cell Aplasia
The pathogenesis of diphenylhydantoin-induced pure red cell aplasia was investigated in the case of a 32-year-old man who developed pure red cell aplasia while he was under treatment with diphenylhydantoin. The patient’s serum lgG purified from serum drawn at the time of diagnosis suppressed normal allogeneic marrow colonyforming (CFU-E) and burst-forming (BFU-E) and autologous blood BFU-E grow...
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ژورنال
عنوان ژورنال: Blood
سال: 1987
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v69.2.394.bloodjournal692394